Where does the data in the PIONEER platform come from?
Data in the PIONEER Big Data Platform is coming from sources all over Europe and the world. We have identified 82 potential prostate cancer data sources from 16 countries. These include data sets from hospitals, research institutes, biobanks and OMICs consortia, the pharmaceutical industry and biotech companies.
Each data source has an associated data fact sheet which allows to assess which data sources contain the most relevant information for a given research question.
In May 2020, 23 data sources have been catalogued and are ready for conversion and import into the PIONEER Big Data Platform.
The first two academic datasets have been made available by PIONEER partner Erasmus University Medical Centre (MC). Erasmus MC have contributed two of the most well-known European datasets to the PIONEER Big Data platform:
- The Prostate Cancer Research International Active Surveillance (PRIAS) study which was initiated in 2006 and has developed into the largest active surveillance study worldwide, with more than 8,000 patients from 120 centres in 18 countries. The primary objective of PRIAS is to provide evidence-based recommendations on how to select and follow men with low-risk prostate cancer on active surveillance.
- The European Randomised study of Screening for Prostate Cancer (ERSPC) Rotterdam. ERSPC was initiated in 1993 and is the largest ever randomised study on screening for prostate cancer, involving 184,000 men in eight countries. The Netherlands patient cohort from Erasmus MC contains more than 42,000 patients. The aim of ERSPC is to investigate the effect of regular prostate-specific antigen (PSA) screening on prostate cancer mortality.
The first Data Sharing Agreement has been signed with external data contributor Active Biotech AB. Active Biotech AB has now shared data collected in a phase 3 randomised, double blind, placebo controlled study of tasquinimod in men with metastatic castrate-resistant prostate cancer. The data from 411 men was collected between 2011 and 2015 and has been shared to the PIONEER platform using the Central data sharing model.
In addition, five industry datasets from three EFPIA partners have been made available in the platform:
- Bayer: CPRD
- Bayer: OPTUM
- Astellas: MarketScan CCAE
- Astellas: MarketScan MDCR
- IQVIA/Astellas: Pharmetrics
Monique Roobol Erasmus MC
Listen to Prof. Monique Roobol from Erasmus MC explain why she believes contributing data to the PIONEER Big Data platform will be game changing of prostate cancer research.